Intermediate filaments take the heat as stress proteins
نویسندگان
چکیده
منابع مشابه
"Prompt" heat shock proteins: translationally regulated synthesis of new proteins associated with the nuclear matrix-intermediate filaments as an early response to heat shock.
The response of mammalian cells, such as HeLa cells, to prolong exposure to increased temperature (termed heat shock) has been well characterized. In these studies new mRNA is synthesized for several proteins whose translation is best seen after a return to 37 degrees C. We show here another response to increased temperature of a distinctively different character. A set of at least 50 newly det...
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The small heat shock protein alphaB-crystallin interacts with intermediate filament proteins. Using a co-sedimentation assay, we showed that in vitro binding of alphaB-crystallin to peripherin and vimentin was temperature-dependent. Specifically, a synthetic peptide representing the first ten residues of alphaB-crystallin was involved in this interaction. When cells were submitted to different ...
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In most vertebrate cells, intermediate filaments (IF) 1 form a continuous structural network extending from the nuclear surface to the cell periphery. Their unique viscoelastic properties render them more resistant than either microtubules or microfilaments to deformation and other external physical stresses. Through a growing family of associated proteins (IFAPs), IF are now known to be connec...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2010
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2009.11.004